Design and analysis of experiments

Learning outcomes

• Learn the basic terminology of experiments: responses, factors, outcomes, real-world units vs coded units, confounding
• Analyze and interpret data from an experiment with 2, 3 or more factors by hand
• Use R to do the analysis, and interpret the various plots, such as the Pareto plot
• Analyze and interpret data from an experiment with 3 or more factors
• Recognize when to use a fractional factorial, to go mostly the same results as from a full factorial
• Understand when to use screening experiments
• Use the concepts of response surface methods to systematically reach an optimum
• What you can do when you make a mistake, or hit against constraints.

Resources

• Class notes 2015 This is a large file, at 219 Mb. You might prefer the smaller set of notes from 2014, but they are less comprehensive.
• Class notes 2014
• Textbook, chapter 5
• You must have completed steps 13, and 16 to 22 of the Software tutorial to successfully use R in this section.
• Take the Coursera course on this topic.
• What experiments are you going to do for your course project? What are the factors, what are the levels? How did you chose your levels? What is your response? How will you measure your response?
• Quizzes (with solutions): attempt these after you have watched the videos

Tasks to do first	Quiz	Solution
Watch videos 1A, 1B, 1C and 1D	Quiz	Solution
Watch videos 2A, 2B, 2C, 3A and 3B (note!)	Quiz	Solution
Watch videos 2D, 3C and 3D and 4A (note!)	Quiz	Solution
Watch videos 4B, 4C, 4D, and 4E	Quiz	Solution
Watch videos 4F, 4G, 4H, 5A and 5B	Quiz	Solution
Watch videos 5C, 5D, 5E and 5F	Quiz	Solution

Extended readings/practice

• Don't accept what is often believed to be true: always experiment.
• In case you've been wondering how the trade-off table was constructed.
• You must cover steps 16, 21 and 22 of the detailed software tutorial to master this section of the course.
• Some extra videos about experimentation, as applied in this course:
  1. Interview 01: Experiments in a non-engineering context, a Hamilton baker: Made for you by Madeleine (05:23)
  2. Interview 02: Dr. Soo Chan Carusone talks about experiments in a medical context (07:16)
  3. Interview 03: David Latulippe and his student Jeff, talk about water treatment experiments (05:46)
  4. Interview 04: An interview with Dr. Joe Kim at McMaster University (10:54)
• Something new to try (09 March 2016): test your knowledge about Design of Experiments by optimizing these systems: http://rsmopt.com

Class videos from prior years

Videos from 2015

Watch all these videos in this YouTube playlist

• 00 - Introduction video for the Coursera online course [01:56]
• 1A - Why experiments are so important [07:48]
• 1B - Some basic terminology [06:37]
• 1C - Analysis of your first experiment [09:00]
• 1D - How NOT to run an experiment [03:07]
• 2A - Analysis of experiments in two factors by hand [13:37]
• 2B - Numeric predictions from two-factor experiments [07:25]
• 2C - Two-factor experiments with interactions [15:15]
• 2D - In-depth case study: analyzing a system with 3 factors by hand [17:28]
• 3A - Setting up the least squares model for a 2 factor experiment [05:46]
• 3B - Solving the mathematical model for a 2 factor experiment using software [08:46]
• 3C - Using computer software for a 3 factor experiment [08:37]
• 3D - Case study: a 4-factor system using computer software [09:03]
• 4A - The trade-offs when doing half-fraction factorials [13:20]
• 4B - The technical details behind half-fractions [09:38]
• 4C - A case study with aliasing in a fractional factorial [06:38]
• 4D - All about disturbances, why we randomize, and what covariates are [11:00]
• 4E - All about blocking [09:21]
• 4F - Fractional factorials: introducing aliasing notation [12:00]
• 4G - Fractional factorials: using aliasing notation to plan experiments [10:45]
• 4H - An example of an analyzing an experiment with aliasing [09:50]
• 5A - Response surface methods - an introduction [06:13]
• 5B - Response surface methods (RSM) in one variable [18:40]
• 5C - Why changing one factor at a time (OFAT) will mislead you [05:33]
• 5D - The concept of contour plots and which objectives should we maximize [03:40]
• 5E - RSM in 2 factors: introducing the case study [19:20]
• 5F - RSM case study continues: constraints and mistakes [13:45]
• 5G - RSM case study continues: approaching the optimum [17:05]
• 06 - Wrap-up: the course in review, multiple objectives, and references for the future [08:10]

Videos from 2014

See the webpage from 2014

Videos from 2013

See the webpage from 2013

Software codes for this section

Code to build a model for a 2-factor system

• Run this code in a web-browser

# Centered and scaled temperature T <- c(-1, +1, -1, +1) # Centered and scaled substrate concentration S <- c(-1, -1, +1, +1) # Conversion is the response, y y <- c(69, 60, 64, 53) # this works, but is more typing mod <- lm(y ~ T + S + T * S) # preferred method mod <- lm(y ~ T * S) summary(mod)

Detailed analysis of the 3 factor example

<rst> <rst-options: 'toc' = False/> The data are from a plastics molding factory which must treat its waste before discharge. The :math:`y` variable represents the average amount of pollutant discharged [lb per day], while the 3 factors that were varied were:

	-	:math:`C`: the chemical compound added [A or B]

- :math:`T`: the treatment temperature [72°F or 100°F] - :math:`S`: the stirring speed [200 rpm or 400 rpm] - :math:`y`: the amount of pollutant discharged [lb per day]

.. tabularcolumns:: |l|l||c|c|c||c|

+-----------+-------+---------------+-----------------+-----------------+-----------------+ | Experiment| Order | :math:`C` | :math:`T` [°F] | :math:`S` [rpm] | :math:`y` [lb] | +===========+=======+===============+=================+=================+=================+ | 1 | 5 | A | 72 | 200 | 5 | +-----------+-------+---------------+-----------------+-----------------+-----------------+ | 2 | 6 | B | 72 | 200 | 30 | +-----------+-------+---------------+-----------------+-----------------+-----------------+ | 3 | 1 | A | 100 | 200 | 6 | +-----------+-------+---------------+-----------------+-----------------+-----------------+ | 4 | 4 | B | 100 | 200 | 33 | +-----------+-------+---------------+-----------------+-----------------+-----------------+ | 5 | 2 | A | 72 | 400 | 4 | +-----------+-------+---------------+-----------------+-----------------+-----------------+ | 6 | 7 | B | 72 | 400 | 3 | +-----------+-------+---------------+-----------------+-----------------+-----------------+ | 7 | 3 | A | 100 | 400 | 5 | +-----------+-------+---------------+-----------------+-----------------+-----------------+ | 8 | 8 | B | 100 | 400 | 4 | +-----------+-------+---------------+-----------------+-----------------+-----------------+

We showed the cube plot for this system in the class on 10 March. From the cube plot we could already see the main factors, and even the **CS** interaction was noticeable.

• **C effect**: There are 4 estimates of :math:`C = \displaystyle \frac{(+25) + (+27) + (-1) + (-1)}{4} = \frac{50}{4} = \bf{12.5}`
• **T effect**: There are 4 estimates of :math:`T = \displaystyle \frac{(+1) + (+3) + (+1) + (+1)}{4} = \frac{6}{4} = \bf{1.5}`
• **S effect**: There are 4 estimates of :math:`S = \displaystyle \frac{(-27) + (-1) + (-29) + (-1)}{4} = \frac{-58}{4} = \bf{-14.5}`
• **CT interaction**: There are 2 estimates of :math:`CT`. Recall that interactions are calculated as the half difference going from high to low. Consider the change in :math:`C` when

- :math:`T_\text{high}` (at :math:`S` high) = 4 - 5 = -1 - :math:`T_\text{low}` (at :math:`S` high) = 3 - 4 = -1 - First estimate = [(-1) - (-1)]/2 = 0 - :math:`T_\text{high}` (at :math:`S` low) = 33 - 6 = +27 - :math:`T_\text{low}` (at :math:`S` low) = 30 - 5 = +25 - Second estimate = [(+27) - (+25)]/2 = +1

- Average **CT** interaction = (0 + 1)/2 = **0.5** - You can interchange :math:`C` and :math:`T` and still get the same result.

• **CS interaction**: There are 2 estimates of :math:`CS`. Consider the change in :math:`C` when

- :math:`S_\text{high}` (at :math:`T` high) = 4 - 5 = -1 - :math:`S_\text{low}` (at :math:`T` high) = 33 - 6 = +27 - First estimate = [(-1) - (+27)]/2 = -14 - :math:`S_\text{high}` (at :math:`T` low) = 3 - 4 = -1 - :math:`S_\text{low}` (at :math:`T` low) = 30 - 5 = +25 - Second estimate = [(-1) - (+25)]/2 = -13

- Average **CS** interaction = (-13 - 14)/2 = **-13.5** - You can interchange :math:`C` and :math:`S` and still get the same result.

• **ST interaction**: There are 2 estimates of :math:`ST`: (-1 + 0)/2 = **-0.5**, calculate in the same way as above.

• **CTS interaction**: There is only a single estimate of :math:`CTS`:

- :math:`CT` effect at high :math:`S` = 0 - :math:`CT` effect at low :math:`S` = +1 - :math:`CTS` interaction = [(0) - (+1)] / 2 = **-0.5**

- You can calculate this also by considering the :math:`CS` effect at the two levels of :math:`T` - Or, you can calculate this by considering the :math:`ST` effect at the two levels of :math:`C`. - All 3 approaches give the same result.

Next, use computer software (see below) to verify that

.. math:: y = 11.25 + 6.25x_C + 0.75x_T -7.25x_S + 0.25 x_C x_T -6.75 x_C x_S -0.25 x_T x_S - 0.25 x_C x_T x_S

The :math:`\mathbf{X}` matrix and :math:`\mathbf{y}` vector used to calculate the least squares model:

.. math:: \begin{bmatrix} 5\\30\\6\\33\\4\\3\\5\\4 \end{bmatrix} &= \begin{bmatrix} +1 & -1 & -1 & -1 & +1 & +1 & +1 & -1\\ +1 & +1 & -1 & -1 & -1 & -1 & +1 & +1\\ +1 & -1 & +1 & -1 & -1 & +1 & -1 & +1\\ +1 & +1 & +1 & -1 & +1 & -1 & -1 & -1\\ +1 & -1 & -1 & +1 & +1 & -1 & -1 & +1\\ +1 & +1 & -1 & +1 & -1 & +1 & -1 & -1\\ +1 & -1 & +1 & +1 & -1 & -1 & +1 & -1\\ +1 & +1 & +1 & +1 & +1 & +1 & +1 & +1\\ \end{bmatrix} \begin{bmatrix} b_0 \\ b_C \\ b_T \\ b_{S} \\ b_{CT} \\ b_{CS} \\ b_{TS} \\ b_{CTS} \end{bmatrix} \\ \mathbf{y} &= \mathbf{X} \mathbf{b} </rst>

The above 3 factor example, but using computer software

• Run this code in a web-browser

# Create the design matrix in a quick way in R x <- c(-1, +1) design <- expand.grid(C=x, T=x, S=x) design C <- design$C T <- design$T S <- design$S y <- c(5, 30, 6, 33, 4, 3, 5, 4) # Full factorial model (you could make errors typing this in) mod.full <- lm(y ~ C + T + S + C*T + C*S + S*T + C*T*S) # This powerful notation will expand all terms up to the 3rd order interactions mod.full <- lm( y ~ C * T * S ) summary(mod.full)

Compare the result from the last line with the manual calculations above.

Quickly calculate, with software, the names of all the interactions terms

• Calculating all combinations of the interactions can be tedious by-hand in larger models.
• Let the computer do the work for you.
• Run this code in a web-browser

print('Two-factor interactions in a 4-factor model') attr(terms.formula( y ~ (A+B+C+D)^2 ), "term.labels") print('Two- and three-factor interactions in a 4-factor model') attr(terms.formula( y ~ (A+B+C+D)^3 ), "term.labels") print('Two-, 3-, and 4-factor interactions in a 4-factor model') attr(terms.formula( y ~ (A+B+C+D)^4 ), "term.labels")

Plot a Pareto plot of all coefficients in a least-squares model

• Run this code in a web-browser

# First create a model to demonstrate. x <- c(-1, +1) design <- expand.grid(C=x, T=x, S=x) C <- design$C T <- design$T S <- design$S y <- c(5, 30, 6, 33, 4, 3, 5, 4) my.model <- lm( y ~ C * T * S ) # The quick way to plot the coefficients: you can supply # the "paretoPlot" function with any least-squares model #library(pid) # The "PID" library is not part of this web-based version # of R. So load it from this server: source('https://yint.org/paretoPlot.R') # And now we can generate the plot: p <- paretoPlot(my.model)

Fractional-factorial example (saturated design) in R, including how to eliminate factors

• The code shows how the Pareto plot is used to find variables with low significance.
• These variables can be eliminated and the model rebuilt without them.
• Run this code in a web-browser

A <- B <- C <- c(-1, +1) design <- expand.grid(A=A, B=B, C=C) A <- design$A B <- design$B C <- design$C # Specify the other factors 4: up to 7 factors plus an # intercept can be estimated from the 8 experiments. D <- A*B E <- A*C F <- B*C G <- A*B*C # The results from the 8 experiments y <- c(77.1, 68.9, 75.5, 72.5, 67.9, 68.5, 71.5, 63.7) mod <- lm(y ~ A + B + C + D + E + F + G) summary(mod) # Visualize the Pareto plot using the PID library #library(pid) # The "PID" library is not part of this web-based version # of R. So load it from this server: source('https://yint.org/paretoPlot.R') paretoPlot(mod) # The factors B, F and D are not important. # Remove and rebuild the model without them. mod.update.1 <- lm(y ~ A + C + E + G) confint(mod.update.1) paretoPlot(mod.update.1) # Notice that the bars are the same length as before. # Can you explain why? # The confidence interval for factor E spans zero. It # might be of practical relevance, but it is not of # statistical relevance. mod.update.2 <- lm(y ~ A + C + G) confint(mod.update.2)

Plot a contour plot of a least-squares DOE model: a system with 2 factors

• Run this code in a web-browser

# First create a model to demonstrate. # Note that this model has a center-point at (0,0) T <- c(-1, +1, -1, +1, 0) S <- c(-1, -1, +1, +1, 0) y <- c(193, 310, 468, 571, 407) # Visualize the surface my.model.round1 <- lm(y ~ T*S) # Note that the interaction is small; # we should observe that in the contour plot summary(my.model.round1) # The PID library can draw contour plots for # any least squares model where there are two factors: # library(pid) # The "PID" library is not part of this web-based version # of R. So load it from this server: source('https://yint.org/contourPlot.R') # Confirms the weak interaction contourPlot(my.model.round1) # Now make the interaction more prominent T <- c(-1, +1, -1, +1, 0) S <- c(-1, -1, +1, +1, 0) y <- c(193, 310, 281, 571, 407) my.model.round2 <- lm(y ~ T*S) # Note the stronger interaction summary(my.model.round2) # Confirms the strong interaction contourPlot(my.model.round2)

Plot a contour plot of a least-squares DOE model: a system with 3 factors

• When you have 3 (or more) factors in a DOE system, you can still use the contourPlot() function in R.
• Except, you need to tell the software which variables you want to see on the \(x\) and \(y\) axes.
• Run this code in a web-browser

# First create a model to demonstrate. 
x <- c(-1, +1)
design <- expand.grid(C=x, T=x, S=x)
C <- design$C
T <- design$T
S <- design$S
y <- c(5, 30, 6, 33, 4, 3, 5, 4)
mod.full <- lm( y ~ C*T*S )

# The summary shows a high C:S interaction, but
# the other interactions are weak. We should confirm
# this in the visualizations that follow next.
summary(mod.full)

# Visualize the surface using the PID library in R
library(pid)

# Any least squares model can be supplied as the first input

# Start by visualizing the C and T factors (little interaction)
contourPlot(mod.full, "C", "T")

# Try the T and S factors (little interaction)
contourPlot(mod.full, "T", "S")

# Try the C and S factor combination (high interaction)
contourPlot(mod.full, "C", "S")

# Change the colour scheme and the plot resolution
contourPlot(mod.full, "C", "S", N=50, colour.function=rainbow)

# In which direction would you go to minimize the response surface?

Bringing it all together: a comprehensive response surface method (RSM) example)

The code is provided here for you to try: http://yint.org/rsm-code